Exploiting Chemical Probes for Identifying Drug Target Proteins
نویسندگان
چکیده
منابع مشابه
Target validation using chemical probes.
Fully profiled chemical probes are essential to support the unbiased interpretation of biological experiments necessary for rigorous preclinical target validation. We believe that by developing a ‘chemical probe tool kit’, and a framework for its use, chemical biology can have a more central role in identifying targets of potential relevance to disease, avoiding many of the biases that complica...
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11 Stevens, B., Spectrochim. Acta, 18, 439 (1962). 12Ferguson, J., J. Chem. Phys., to be published. 13 Abbreviations for the synthetic polynucleotides and their hydrogen-bonded states are those of Inman, R. B., and R. L. Baldwin, J. Mol. Biol., 5, 172 (1962). 14 Davidson, N., J. Widholm, U. S. Nandi, R. Jensen, B. M. Olivera, and J. C. Wang, these PROCEEDINGS, 53, 111 (1965). 11 Chamberlin, M. ...
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ژورنال
عنوان ژورنال: Journal of the Mass Spectrometry Society of Japan
سال: 2003
ISSN: 1340-8097,1880-4225
DOI: 10.5702/massspec.51.492